Antimikrobielle Peptide Dissertation

Antimikrobielle Peptide Dissertation-1
The present thesis focuses on improving the antimicrobial activity of AMPs by using different strategies like synthesis of AMP-conjugates, membrane immobilization of AMPs, and amino acid exchanges within the AMP sequence.For this, multiple imidazolium-salts, already described as antibacterial agents, were conjugated to AMPs via solid phase peptide synthesis, developing a branched conjugate.Combination of both compounds resulted in a higher antimicrobial activity against multi-resistant bacterial strains.

The present thesis focuses on improving the antimicrobial activity of AMPs by using different strategies like synthesis of AMP-conjugates, membrane immobilization of AMPs, and amino acid exchanges within the AMP sequence.

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